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*Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids*

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If simple measures do not provide relief within two to three weeks, further medical review is appropriate to exclude other causes and consider alternative supplementation routes

One study showed NR at 300 mg/day increased human blood NAD+ ~50% after 8 weeks, whereas higher doses (1000 mg/day) roughly doubled NAD+ levels